MicroRNAs as Important Players in Host-hepatitis B Virus Interactions
MicroRNAs as Important Players in Host-hepatitis B Virus Interactions作者机构：Viral Hepatitis Laboratory Virology Unit Institut Pasteur du Maroc Casablanca Morocco Laboratory of Biology and Health URAC34 Faculty of Sciences Ben M'sik University Hassan Ⅱ Casablanca Morocco
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2015年第3卷第2期
页 面：149-161页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：MicroRNA Hepatitis B virus Host-virus interaction Gene expression Biomarker
摘 要：Hepatitis B virus (HBV) infection,a major public health problem,causes acute and chronic hepatitis that is often complicated by liver cirrhosis and hepatocellular *** pathogenic mechanisms of HBV-related liver disease are not well understood,and the current licensed therapies are not effective in permanently clearing virus from the *** recent years,the role of micro-ribonucleic acids (miRNAs) in HBV infection has attracted great *** miRNAs can influence HBV replication directly by binding to HBV transcripts and indirectly by targeting cellular factors relevant to the HBV life *** are also involved in the regulation of cellular genes and signaling pathways that have critical roles in HBV *** infection,in turn,can trigger changes in cellular miRNA expression that are associated with distinctive miRNA expression profiles depending on the phase of liver *** alterations in miRNA expression have been linked to disease progression and *** provide here an up to date review regarding the field of miRNAs and HBV interplay and highlight the potential utility of miRNAs as diagnostic biomarkers and therapeutic targets for the management of HBV-related liver disease.
维普期刊数据库