A Novel Stereoselective Synthesis of 8-O-4' Neolignans

作     者：Xiao Chuan CHEN Wen Xin GU Xiao Bi JING Xin Fu PAN 

作者机构：Department of ChemistryNational Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000 

出 版 物：《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期：2001年第12卷第2期

页      面：109-110页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China (No.29972015) 

主　　题：8-O-4’ Neolignans ferulic acid addition Mitsunobu reaction stereoselective synthesis 

摘      要：1-(4-hydroxy-3-methoxyphenyl)-2-(4-formyl-2-methoxyphenoxy)-propane-1,3-diol. A 8-O-4 neolignan, has been stereoselectively synthesized in eight steps from ferulic acid, and the directly cis opening of epoxide in eposidation and Mitsunobu reaction were used ingeniously as two key steps with high stereoselectively.