Antioxidant activity of bovine serum albumin binding amino acid Schiff-bases metal complexes

作     者：Rong Min Wang Juan Juan Mao Jing Feng Song Cai Xia Huo Yu Feng He 

作者机构：Key Laboratory of Polymer Materials of Gansu Province Institute of Polymer Northwest Normal University Lanzhou 730070 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2007年第18卷第11期

页      面：1416-1418页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：3ZS061-A25-036 National Natural Science Foundation of China,NSFC: 20274034 Ministry of Education of the People's Republic of China,MOE: 207120 Program for New Century Excellent Talents in University,NCET 

主　　题：Natural polymer Schiff-base metal complexes Glutamic acid Bovine serum albumin (BSA) Antioxidants Hydroxyl radicals 

摘      要：Glutamic acid-salicylaldehyde Schiff-base metal complexes are bound into bovine serum albumin （BSA）, which afforded BSA binding Schiff-base metal complexes （BSA-SalGluM, M=Cu, Co, Ni, Zn）. The BSA binding metal complexes were characterized by UV-vis spectra and Native PAGE. It showed that the protein structures of BSA kept after coordinating amino acid Schiff-bases metal complexes. The effect of the antioxidant activity was investigated. The results indicate that the antioxidant capacity of BSA increased more than 10 times after binding Schiff-base metal complexes.