Heart Valve Injury Induced by Mediastinum Radiotherapy in Cancer Treatment

作     者：Patricia Fraga Paiva Alice Assumpcao Soares Guilherme Sotto Maior do Valle Pinheiro Carolina Fraga Paiva Gisele Maria Campos Fabri Emanoel Guimaraes Paiva Carlos M. Campos Jose Fabfi Junior 

作者机构：Medicine School Faculty of Medical Sciences and Health of Juiz de Fora Suprema/Therezinha de Jesus Hospital and Maternity33 Dirceu de Andrade St. Juiz de Fora MG 36025-140 Brazil Nursing School Faculty of Medical Sciences and Health of Juiz de Fora Suprema/Therezinha de Jesus Hospital and Maternity 33Dirceu de Andrade St. Juiz de Fora MG 36025-140 Brazil Dentistry School Juiz de Fora Federal University Jose Lourengo Kelmer St. s/n Martelos Juiz de Fora MG 36036-330 Brazil Intensive Care and Emergency Rooms Santa Casa de Misericordia Hospital 3353 Barao do Rio Branco Ave Juiz de Fora MG36021-630 Brazil Department of lnterventional Cardiology Heart Institute (InCor) Sao Paulo University Sao Paulo SP 05403-000 Brazil Hospital Israelita Albert Einstein 44 Doctor Eneas de Carvalho Aguiar St Cerqueira Cesar Sao Paulo SP 05403-000 Brazil 

出 版 物：《Journal of Pharmacy and Pharmacology》 (药剂与药理学（英文版）)

年 卷 期：2018年第6卷第6期

页      面：578-586页

学科分类：0710[理学-生物学] 080704[工学-流体机械及工程] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0807[工学-动力工程及工程热物理] 0901[农学-作物学] 090102[农学-作物遗传育种] 

主　　题：Radiation induced valvular disease radiation cardiotoxicity chemotherapy cardiotoxicity cancer related valvular disease. 

摘      要：Radiotherapy as monotherapy or in combination with chemotherapy, has contributed to the drop in mortality rates related to neoplasms in the last 60 years. However, irradiation may promote heart damage and involvement is very common. As a result, VHD （valvular heart disease） is one of the earliest cardiovascular events post-radiotherapy. What it concerns to valve disease induced by chemotherapeutics, there are still only few studies. However, patients treated with chemotherapy in combination with radiotherapy had twice the risk of developing the disease when compared to those treated by radiotherapy alone. The heart injury caused by radiotherapy begins with damage to the endothelium and results in fibrosis and diffuses calcification primarily of the mitral and aortic valves. The echocardiography is the tool of choice to the patient’s assessment and follow-up after exposure. Prevention is the best option to face the valve damage induced by radiation.