Disulfide-crosslinked Poly（L-glutamic acid） Grafted Mesoporous Silica Nanoparticles and Their Potential Application in Drug Delivery

作     者：WU Huiyong LI Jianhui WEI Junchao DAI Yanfeng PENG Zhiping CHEN Yiwang LIU Tianxi 

作者机构：Department of Chemistry Nanchang University Nanchang 330031 P. R. China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Shanghai 200433 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2015年第31卷第5期

页      面：890-894页

核心收录：

学科分类：081703[工学-生物化工] 081704[工学-应用化学] 08[工学] 0817[工学-化学工程与技术] 081701[工学-化学工程] 0836[工学-生物工程] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 

基　　金：Supported by the National Natural Science Foundation of China(Nos.51203073  51463013  51263017) and the Natural Science Foundation of Jiangxi Province  China(Nos.20142BAB203018  20151BAB206011) 

主　　题：Mesoporous silica nanoparticle Redox responsive Drug delivery Surface modification Hybrid 

摘      要：Poly（L-glutamic acid）（PLGA） was grafted onto the surface of mesoporous silica nanoparticles（MSN） via the ring opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride（BLG-NCA） and its subsequent deprotection of benzyl groups. The PLGA chains were cross-linked with cystamine, and thus forming a type of redox responsive drug delivery system（MSN-cPLGA）. The structures were characterized by Fourier transform infrared spectrometry（FTIR）, transmission electron microscopy（TEM） and energy disperse spectrometry（EDS）, demonstrating that disulfide groups existed on the surfaces of MSN-cPLGA particles. The thermal gravimetric analysis（TGA） results show that the PLGA mass fraction is about 33.4% in the MSN-cPLGA hybrid. The in vitro drug release experiments showed that the MSN-cPLGA hybrid can realize the controlled release of model drugs（5-fluorouracil） in response to redox environment. Even 0.1 mmol/L dithiothreitol（DTT） can accelerate the drug release speed, and a concentration of 10.0 mmol/L DTT is higher enough to trigger the open of cross-linked PLGA network so as to realize rapid release of drugs. All the results demonstrate that the cross-linked PLGA chains on the surface of MSN could act as efficient gatekeepers to control the on-off of the pores, showing potential application in drug delivery system.