What can computational modeling offer for studying the Ca^(2+) dysregulation in Alzheimer's disease:current research and future directions

作     者：Jingyi Liang Don Kulasiri 

作者机构：Centre for Advanced Computational Solutions(C-fACS)Lincoln University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第7期

页      面：1156-1158页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

主　　题：Alzheimer's disease amyloid-beta Ca^2+ hypothesis Ca^2+ dysregulation computational modeling computational neuroscience 

摘      要：Ca^2＋ dysregulation is an early event observed in Alzheimer＇s disease（AD） patients preceding the presence of its clinical *** of neuronalCa^2＋ will cause synaptic loss and neuronal death,eventually leading to memory impairments and cognitive *** targetingCa^2＋ signaling pathways are potential therapeutic strategies against *** complicated interactions make it challenging and expensive to study the underlying mechanisms as to how Ca^2＋ signaling contributes to the pathogenesis of *** modeling offers new opportunities to study the signaling pathway and test proposed *** this mini-review,we present some computational approaches that have been used to study Ca^2＋ dysregulation of AD by simulating Ca^2＋signaling at various *** also pointed out the future directions that computational modeling can be done in studying the Ca^2＋ dysregulation in AD.