The Ever Expanding Role of Ubiquitin and SUMO in Plant Biology

作     者：Giovanna Serino Qi Xie 

作者机构："Charles Darwin" Department of Biology and Biotechnology Sapienza Università di Roma Laboratory of Plant Molecular Signaling Institute of Genetics and Developmental Biology Chinese Academy of Sciences 

出 版 物：《Journal of Integrative Plant Biology》 (植物学报（英文版）)

年 卷 期：2013年第55卷第1期

页      面：5-6页

核心收录：

学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学] 

基　　金：supported by an Executive Programme of Scientific and Technological Cooperation between Italy and China 2010-2012 the National Science Foundation of China 31030047 

主　　题：SUMO The Ever Expanding Role of Ubiquitin and SUMO in Plant Biology 

摘      要：When it was discovered in the 1970s as a ubiquitous protein, ubiquitin, a 76-aminoacid peptide, had no assigned function. It was not until later that ubiquitin was found to be a necessary cofactor in a vital cellular process： the degradation of proteins. Work by Avram Hershko, Aaron Ciechanover, and Irwin Rose （for which they received the 2004 Nobel Prize in Chemistry） showed that the covalent attachment of ubiquitin provide pro-teins with a tag that dispatches them to the proteasome, the main cell degradation machinery （Ciechanover 2012）. Subsequent work, has revealed that ubiquitin belongs to a broader family of ubiquitin-like proteins that can modify not only protein stability, but also subcellular localization and function.