Association of primary biliary cirrhosis with idiopathic thrombocytopenic purpura

作     者：Nobuyuki Toshikuni Ryumei Yamato Haruhiko Kobashi Ken Nishino Nobu Inada Ritsuko Sakanoue Mitsuhiko Suehiro Yoshinori Fujimura Gotaro Yamada 

作者机构：Department of Internal Medicine Center for Liver Diseases Kawasaki Hospital Kawasaki Medical School Okayama 7008505 Japan Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 7008558 Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第15期

页      面：2451-2453页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Primary biliary cirrhosis Idiopathic thrombocytopenic purpura Anti-platelet autoantibody Platelet surface glycoprotein complex Human leukocyteantigen 

摘      要：Although both primary biliary cirrhosis (PBC) and idiopathic thrombocytopenic purpura (ITP) are autoimmune diseases, the association of the 2 diseases is rare. Here, we report a case of ITP that developed during the follow-up of PBC in a 74-year- old man. The patient had been diagnosed with PBC 12 years previously, and had received treatment with ursodeoxycholic acid. The platelet count decreased from approximately 60 × 109/L to 8 × 109/L, and the association of decompensated liver cirrhosis (PBC) with ITP was diagnosed. Steroid and immune gamma globulin therapy were successful in increasing the platelet count. Interestingly, human leukocyte antigen genotyping detected the alleles DQB10601 and DRB10803, which are related to both PBC and ITP in Japanese patients. This case suggests common immunogenetic factors might be involved in the development of PBC and ITP.