Dextran-modified iron oxide nanoparticles
Dextran-modified iron oxide nanoparticles作者机构：Institute of Macromolecular Chemistry Academy of Sciences of the Czech Republic Heyrovsky Sq. 2 162 06 Prague Czech Republic
出 版 物：《China Particuology》 (China Particuology)
年 卷 期：2007年第5卷第1期
页 面：162-168页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：Grantová Agentura České Republiky GA ČR (203/05/2256)
主 题：Iron oxide Nanoparticles Dextran Size-exclusion chromatography Particle size
摘 要：Dextran-modified iron oxide nanoparticles were prepared by precipitation of Fe（Ⅱ） and Fe（Ⅲ） salts with ammonium hydroxide by two methods. Iron oxide was precipitated either in the presence of dextran solution, or the dextran solution was added after precipitation. In the second method, the iron oxide particle size and size distribution could be controlled depending on the concentration of dextran in the solution. The nanoparticles were characterized by size-exclusion chromatography, transmission electron microscopy and dynamic light scattering. Optimal conditions for preparation of stable iron oxide colloid particles were determined, The dextran/iron oxide ratio 0-0,16 used in precipitation of iron salts can be recommended for synthesis of nanoparticles suitable for biomedical applications, as the colloid does not contain excess dextran and does not coagulate.
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