Apoptosis in Primary Oral Squamous Cell Carcinomas without Lymph Node Metastases
Apoptosis in Primary Oral Squamous Cell Carcinomas without Lymph Node Metastases作者机构：Medical Cosmetic Surgery Center Wuhan First Hospital (International) Wuhan 430030 China Hubei Health Care of Women and Children Hospital Wuhan 430070 China Center of Stomatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China
出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)
年 卷 期：2005年第25卷第1期
页 面：109-110页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：carcinoma, squamous cell apoptosis TUNEL
摘 要：The apoptosis in primary oral squamous cell carcinomas (OSCCs) without lymph node (LN) metastases and its relation with clinical stages and pathological grades was investigated. The terminal deoxynucleotidyl trasferase (TdT)-mediated dUTP nick end labeling (TUNEL) was used to detect the apoptotic cells in 15 cases of OSCCs. The percentage of apoptotic cells among tumor cells were calculated as apoptotic index (AI). The results showed that in all 15 cases of OSCCs, apoptotic cells could be visualized by TUNEL with AI ranging from 0.03 to 0.92 (average 0.32). AI was significantly negatively correlated with pathological grades (P0.05). It was concluded that the apoptotic rate was related to the malignant degree of OSCCs without LN metastases.
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