Enantioselective epoxidation of olefins with hydrogen peroxide catalyzed by bioinspired aminopyridine manganese complexes derived from L-proline

作     者：Wenfang Wang Qiangsheng Sun Chungu Xia Wei Sun 王文芳;孙强盛;夏春谷;孙伟

作者机构：State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 Gansu China University of Chinese Academy of Sciences Beijing 100049 China 

出 版 物：《Chinese Journal of Catalysis》 (催化学报（英文）)

年 卷 期：2018年第39卷第9期

页      面：1463-1469页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(21473226,21773273) Key Research Program of Frontier Sciences,CAS(QYZDJ-SSW-SLH051) Natural Science Foundation of Jiangsu Province(BK20170420) 

主　　题：Aminopyridine ligand Manganese Asymmetric ep oxidation Hydrogen peroxide Olefin 

摘      要：Three chiral aminopyridine ligands derived from L-proline were prepared. Careful evaluation of the corresponding aminopyridine manganese complexes in asymmetric epoxidation of olefins revealed a broad substrate scope in the presence of 0.2 mol% manganese complex and 0.5 equiv. 2,2-dimethylbutyric acid, with aqueous hydrogen peroxide as an oxidant. A variety of olefins including styrenes, chromenes, and cinnamamides were transformed successfully into the target epoxides with moderate to excellent enantioselectivity（yield up to 95%, ee up to 99%）.