Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis
作者机构：Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Interventional OncologyThe First Affiliated HospitalSun Yat-sen UniversityNo.58Zhongshan Second RoadGuangzhou 510080GuangdongP.R.China Department of Thoracic SurgerySecond Hospital of Lanzhou UniversityLanzhou 730030GansuP.R.China Department of RadiologyAffiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou 510060GuangdongP.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2018年第38卷第1期
页 面：170-178页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Type 2 diabetes mellitus Esophageal cancer Prognosis Overall survival
摘 要：Background:The association between type 2 diabetes mellitus(T2DM)and the risk of esophageal cancer remains *** present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival in patients with esophageal squamous cell cancer(ESCC).Methods:The present retrospective study included 862 patients diagnosed with ESCC between January 2001 and December *** them,280 patients had T2DM.A 1:1 propensity score-matched cohort consisting of 280 patients with and 280 without T2DM was selected from the 862 *** associations between T2DM and clinico-pathologic characteristics were assessed using theχ2 or Fisher’s exact *** of ESCC patients with and without T2DM was calculated by using the Kaplan-Meier method and compared by using the Cox regression model between the two ***:The occurrence rate of anastomotic leakage was significantly higher in patients with T2DM than in those without T2DM(P5.05%,the patients without T2DM showed a longer survival(P=0.001).Univariate and multivariate analysis results showed that T2DM was not an independent prognostic factor for patient ***:Type 2 diabetes mellitus is not an independent prognostic factor in patients with ***,the combination of T2DM with severe weight loss would be a predictor of poor prognosis.
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