NKT cells in liver diseases
NKT cells in liver diseases作者机构：CAS Key Laboratory of Innate Immunity and Chronic Disease CAS Center for Excellence in Molecular Cell Science School of Life Sciences and Medical Center University of Science and Technology of China Hefei 230027 China Innovation Center for Cell Signaling Network Hefei National Laboratory for Physical Sciences at Microscale Hefei 230027 China
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2018年第12卷第3期
页 面：249-261页
核心收录：
学科分类：080705[工学-制冷及低温工程] 090603[农学-临床兽医学] 1002[医学-临床医学] 08[工学] 0807[工学-动力工程及工程热物理] 09[农学] 0906[农学-兽医学]
基 金：Work in the authors＇ laboratory was supported by National Natural Science Foundation of China （Nos. 91542203 31470859 and 81771671） National Key R＆D Program of China （No. 2017YFA0505300） the Strategic Priority Research Program of the Chinese Academy of Sciences （No. XDA12030208） the Fundamental Research Funds for the Central Universities.
主 题：natural killer T cells hepatitis B virus and hepatitis C virus infection autoimmune liver diseases alcoholic liverdisease nonalcoholic fatty liver disease hepatocellular carcinoma
摘 要：Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma. Controversial results from previous studies are discussed, and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver diseases, which might be caused by changes in natural killer T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer T cells and CDld-expressing cells or bystander cells.
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