Oxidation-induced ortho-selective C–H bond functionalization of 2-naphthylamine derivative

作     者：Dongchao Zhang Zhiliang Huang Aiwen Lei 

作者机构：The Institute for Advanced Studies College of Chemistry and Molecular Sciences Wuhan University National Research Center for Carbohydrate Synthesis Jiangxi Normal University 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2018年第61卷第10期

页      面：1274-1277页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China (21390402, 21520102003, 21702150) the National Basic Research Program of China (2012CB725302) the CAS Interdisciplinary Innovation Team and the Hubei Province Natural Science Foundation of China (2017CFA010) China Postdoctoral Science Foundation (BX201600114, 2016M602340) 

主　　题：oxidation-induced C-H bond functionalization ortho-selectivity 

摘      要：Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed as one of the most efficient methods for selective C–H functionalization. Although a great progress has been made by utilizing this traditional method, developing new strategy for selective C–H bond functionalization is still highly demanded. Hence, a novel oxidation-induced C–H bond functionalization method was demonstrated in this work. By this new method, ortho-C(sp2)–H chlorination of N-substituted 2-naphthylamine was realized in a highly selective manner.