Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics

作     者：Kelsy Robinson Xi Ma Yulan Liu Shiyan Qiao Yongqing Hou Guolong Zhang 

作者机构：Department of Animal ScienceOklahoma State University State Key Laboratory of Animal NutritionCollege of Animal Science and TechnologyChina Agricultural University Hubei Collaborative Innovation Center for Animal Nutrition and Feed SafetyHubei Key Laboratory of Animal Nutrition and Feed ScienceWuhan Polytechnic University 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2018年第4卷第2期

页      面：160-169页

核心收录：

学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 0906[农学-兽医学] 09[农学] 

基　　金：supported in part by Oklahoma Center for the Advancement of Science and Technology grants(AR12.2-077,HR12-051,and AR15.049) Oklahoma Agricultural Experiment Station Project(H-3025) National Science Foundation of China grant(31528018) supported by a USDA-NIFA National Needs Fellowship grant(2013-38420-20500) 

主　　题：Host defense peptides Antibiotic alternatives Butyrate Vitamin D Antibiotics 

摘      要：Traditionally, antibiotics are included in animal feed at subtherapeutic levels for growth promotion and disease ***, recent links between in-feed antibiotics and a rise in antibiotic-resistant pathogens have led to a ban of all antibiotics in livestock production by the European Union in January 2006 and a removal of medically important antibiotics in animal feeds in the United States in January *** urgent need arises for antibiotic alternatives capable of maintaining animal health and productivity without triggering antimicrobial *** defense peptides(HDP) are a critical component of the animal innate immune system with direct antimicrobial and immunomodulatory *** in-feed supplementation of recombinant or synthetic HDP appears to be effective in maintaining animal performance and alleviating clinical symptoms in the context of disease, dietary modulation of the synthesis of endogenous host defense peptides has emerged as a cost-effective,antibiotic-alternative approach to disease control and *** different classes of smallmolecule compounds have been found capable of promoting HDP *** the most efficacious compounds are butyrate and vitamin ***, butyrate and vitamin D synergize with each other in enhancing HDP *** review will focus on the regulation of HDP synthesis by butyrate and vitamin D in humans, chickens, pigs, and cattle and argue for potential application of HDP-inducing compounds in antibiotic-free livestock production.