Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer

作     者：Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li 

作者机构：Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing)Department of Breast OncologyPeking University Cancer Hospital & Institute Helen Diller Family Comprehensive Cancer CenterUniversity of California CAS Key Laboratory of Standardization and Measurement for Nanotechnologythe National Center for Nanoscience and Technology of China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing)Department of Clinical LaboratoryPeking University Cancer Hospital & Institute 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2018年第30卷第3期

页      面：315-326页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National Natural Science Foundation of China (No.81502269 and No.21273051) a grant from the Chinese Academy of Sciences (No.XDA09030306) 

主　　题：Breast cancer nanotechnology circulating tumor cell immunology 

摘      要：Objective：Triple-negative breast cancer（TNBC）is a heterogeneous disease with poor *** tumor cells（CTCs）are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival（PFS）is *** aim to verify their predictive value in ***：In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC（taken at inclusion in this study）and analyzed correlations between CTC numbers and outcomes and other clinical ***：Median PFS was 6.0（range：1.0–25.0）months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage（P=0.167）,tumor grade（P=0.783）or histological type（P=0.084）.However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer（NK）cells（P=0.032）,presence of lung metastasis（P=0.034）and number of visceral metastatic site（P=0.037）.Baseline CTC status was predictive for PFS in first-line TNBC（P=0.033）,but not for the cohort as a whole（P=0.118）.This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration（P=0.049）.Conclusions：Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line *** have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions.