Sepsis and immune response
Sepsis and immune response作者机构：Department of Emergency Medicine Second Hospital of Jilin University Changchun 130041 China
出 版 物：《World Journal of Emergency Medicine》 (世界急诊医学杂志（英文）)
年 卷 期：2011年第2卷第2期
页 面：88-92页
学科分类：0401[教育学-教育学] 04[教育学] 040110[教育学-教育技术学（可授教育学、理学学位）]
主 题：Sepsis Immune response Inflammatory mediator
摘 要：BACKGROUND： Sepsis and secondary multiple organ failure in critically ill patients are the major cause of death, but the pathogenesis of sepsis is not clear, especially the dysfunction of the immune system. In this paper, we review the response and regulation of the immune system and the functions of a variety of inflammatory mediators in sepsis. DATA SOURCES Studies were identified by searching MEDLINE and PubMed for articles using the keywords ＂sepsis＂, ＂immune response＂, and ＂inflammatory mediator＂ up to October 2010. Additional papers were identified by a manual search of the references from the key ***： This systematic review was conducted of： 1） the immune response; 2） immune regulation; 3） inflammatory mediators; 4） high-mobility group box 1 protein; 5） the complement system; and 6） the autonomic nervous system. There are no therapeutic approaches available for sepsis that target inflammatory response; the mortality of sepsis has not been significantly reduced. Sepsis is complex and dynamic, and it has a group of heterogeneous ***： Since different patients with sepsis have different etiology, susceptibility, and responses, treatment should be prescribed individually.
维普期刊数据库