Molecularly Imprinted Polymer for Theophylline Retention and Molecular Recognition Properties in Capillary Electrochromatography

作     者：CaiLing-shuang WuCai-ying MeiSu-rong ZengZao-rui 

作者机构：CollegeofChemistryandMolecularSciencesWuhanUniversityWuhan430072HubeiChina 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：2004年第9卷第3期

页      面：359-365页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 100701[医学-药物化学] 10[医学] 

基　　金：SupportedbytheNationalNatureScienceFoundationofChina (2 0 3750 2 8)andtheResearchFundfortheNationalHighTechnol ogyDevelopment"863"ofChina (2 0 0 2AA2Z2 0 0 4 ) 

主　　题：capillary electrochromatography molecular imprinting polymers theophylline 

摘      要：Molecular imprinting of theophylline in poly (methacrylic acid- ethylene dimethacrylate) as CEC stationary phases was synthesized by an in situ photo-initiated polymerization reaction. The effect of electrolyte pH on xanthine derivatives and the stability of MIP column performance were investigated. the relative standard deviation (D RS) of migration time of five consecutive runs on MIP column was in the range of 2.2%–3.1%. The reproducibility of migration time column to column of M(A) was in the range of 3.8%–4.9%. The highest column efficiency was more than 140 000 plates per meter. The MIP capillaries had showed better selective for theophylline, which comparing with the reference column. The urine sample was separated by spiked 5×10?4 mol·L?1 theophylline. Key words capillary electrochromatography - molecular imprinting polymers - theophylline CLC number O 657.8 Foundation item: Supported by the National Nature Science Foundation of China (20375028) and the Research Fund for the National High Technology Development “863 of China (2002AA2Z2004) Biography: Cai Ling-shuang (1968-), female, Associate professor, Ph. D, research direction: separation science.