Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics

作     者：Yewei Liu Qian Reuben Xie Boshi Wang Jiaxiang Shao Tingting Zhang Tengyuan Liu Gang Huang Weiliang Xia 

作者机构：School of Biomedical Engineering and Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China De partment of Nuclear MedicineRenji HospitalSh anghai Jiao Tong University School of MedicineShanghai 200127China C linical Stem Cell CenterRenji HospitalSh anghai Jiao Tong University School of MedicineShanghai 200127China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2013年第4卷第9期

页      面：702-710页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 0703[理学-化学] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学] 

基　　金：The study was supported by research grants from National Natural Science Foundation of China(Grant Nos.30830038,30970842,81071180,30900756 and 31270032) the National Basic Research Program(973 Program)(No.2012CB932604) New Drug Discovery Project(2012ZX09506-001-005) Key Project of Science and Tech-nology Commission of Shanghai Municipality(No.10JC1410000) Shanghai Leading Academic Discipline Project(No.S30203) 

主　　题：SI RT6 overexpression prostate cancer th erapy 

摘      要：SI RT6 is an important histone modifying protein that regulates DNA repair,telomere maintenance,energy me-tabolism,and target gene *** SIRT6 has been identifi ed as a tumor suppressor and is down-regulated in certain cancer types,but not in other *** deposited gene profi ling studies we found that SIRT6 was overexpressed in prostate tumors,compared with normal or paratumor prostate *** micro-array studies confi rmed the higher levels of SIRT6 in both prostate tumor tissues and prostate cancer cells than in their normal *** of SIRT6 in human prostate cancer cells led to sub-G1 phase arrest of cell cy-cle,increased apoptosis,elevated DNA damage level and decrease in BCL2 gene ***,SIRT6-de-fi ciency reduced cell viability and enhanced chemothera-peutics *** together,this study provides the fi rst evidence of SIRT6 overexpression in human prostate cancer,and SIRT6 regulation could be exploited for pros-tate cancer therapy.