An epigenetic view of developmental diseases: new targets, new therapies
作者机构：Institute of GeneticsCollege of Life SciencesZhejiang University Children's HospitalZhejiang University School of Medicine Institute of Translational MedicineSchool of MedicineZhejiang University
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2016年第12卷第3期
页 面：291-297页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the International Collaboration Program of Science Technology Department of Zhejiang Province(2015C34001 2016C34004)to Shu Q and Li XQ Zhejiang Provincial Program for the Cultivation of Highlevel Innovative Health talents to Shu Q the National Key Basic Research Program of China(No.2014CB943001) National Natural Science Foundation of China(No.31371309)to Li XQ
主 题：congenital heart disease development DNA modifi cation 5-hydroxymethylcytosine neurological disorders RNA modifi cation
摘 要：Background:Function of epigenetic modifications is one of the most competitive fields in life *** the past several decades,it has been revealed that epigenetic modifications play essential roles in development and diseases including developmental *** the present review,we summarize the recent progress about the function of epigenetic regulation,especially DNA and RNA modifi cations in developmental *** sources:Original research articles and literature reviews published in PubMed-indexed ***:DNA modifications including methylation and demethylation can regulate gene expression,and are involved in development and multiple diseases including Rett syndrome,Autism spectrum disorders,congenital heart disease and cancer,*** methylation and demethylation play important roles in RNA processing,reprogramming,circadian,and neuronal activity,and then modulate ***:DNA and RNA modifications play important roles in development and diseases through regulating gene *** components could serve as novel targets for the treatment of developmental diseases.
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