Origin and molecular characterization of the human-infecting H6N1 infl uenza virus in Taiwan

作     者：Weifeng Shi Yi Shi Ying Wu Di Liu George F.Gao 

作者机构：School of Medical SciencesTaishan Medical CollegeTaian 271016China CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China Beijing Institutes of Life SciencesChinese Academy of SciencesBeijing 100101China Network Information CenterInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China Offi ce of Director-GeneralChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2013年第4卷第11期

页      面：846-853页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 0906[农学-兽医学] 09[农学] 0703[理学-化学] 0836[工学-生物工程] 

基　　金：the National Basic Research Pro-gram(973 Program)(Nos.2010CB530303,2011CB504703,and 2012CB955501 an intramural special grant for influenza virus research from the Chinese Academy of Sciences(KSZD-EW-Z-002) the Doctoral Starting up Foundation of Taishan Medical College.GFG is a leading principal investigator of the Innova-tive Research Group of the National Natural Science Foundation of China(Grant No.81021003) 

主　　题：molecular characterization phylogenetic analysis coalescent analysis H6N1 infl uenza virus Taiwan 

摘      要：In June 2013,the fi rst human H6N1 infl uenza virus infec-tion was confirmed in ***,the origin and molecular characterization of this virus,A/Taiwan/2/2013(H6N1),have not been well studied thus *** the present report,we performed phylogenetic and coalescent analy-ses of this virus and compared its molecular profi le/char-acteristics with other closely related *** characterization of H6N1 revealed that it is a typical avian infl uenza virus of low pathogenicity,which might not rep-licate and propagate well in the upper airway in *** analysis revealed that the virus clusters with A/chicken/Taiwan/A2837/2013(H6N1)in seven genes,except *** the PB1 gene,A/Taiwan/2/2013 was clus-tered with a different H6N1 lineage from A/chicken/Taiwan/A2837/*** a previous study demonstrated that the PB2,PA,and M genes of A/Taiwan/2/2013 might be derived from the H5N2 viruses,coalescent analyses revealed that these H5N2 viruses were derived from more recent strains than that of the ancestor of A/Taiwan/2/***,we propose that A/Taiwan/2/2013 is a reassor-tant from different H6N1 lineages circulating in chickens in ***,compared to avian isolates,a sin-gle P186L(H3 numbering)substitution in the hemaggluti-nin H6 of the human isolate might increase the mammali-an receptor binding and,hence,this strain’s pathogenicity in ***,human infection with this virus seems an accidental event and is unlikely to cause an infl uenza ***,its co-circulation and potential reas-sortment with other infl uenza subtypes are still worthy of attention.