Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner

作     者：Xia Xu Qinghong Meng Ulrike Erben Peigang Wang Rainer Glauben Anja A Kühl Hao Wu Chung Wah Ma Minghua Hu Yuanyuan Wang Wei Sun Junying Jia Xinyi Wu Wei Chen Britta Siegmund Zhihai Qin 

作者机构：Key Laboratory of Protein and Peptide PharmaceuticalsChinese Academy of Sciences-University of Tokyo Joint Laboratory of Structural Virology and ImmunologyInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of SciencesBeijing 100049China Medical Department for GastroenterologyInfectious Diseases and Rheumatology/Research Center ImmunoSciencesCampus Benjamin FranklinCharité-Universitätsmedizin BerlinBerlin 12200Germany Infinitus Chinese Herbal Immunity Research CentreGuangzhou 510665China Berlin Institute for Medical Systems BiologyMax Delbrück Center for Molecular Medicine Berlin-BuchBerlin 13125Germany 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2017年第14卷第7期

页      面：597-606页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Ministry of Science and Technology of China(2012CB917103,2012CB934003) the National Natural Science Foundation of China(91229203) the German Research Foundation(DFG 749-6/1 and SFB 633) 

主　　题：B cells IgA MDSCs TNFR2 

摘      要：Myeloid-derived suppressor cells(MDSCs)are well known for their capacity to suppress antitumor T-cell responses,but their effects on B-cell function and antibody production remain ***,we found that MDSCs that accumulated around the germinal center in the spleen of tumor-bearing mice co-located with B *** the presence of MDSCs,the antibody reaction to a surrogate antigen was significantly enhanced in mice,especially the immunoglobulin(Ig)A ***-culture with MDSCs promoted both proliferation and differentiation of B cells into IgA-producing plasma cells in ***,the cross talk between MDSCs and B cells required cell-cell *** from tumor necrosis factor receptor(TNFR)2^(−/−)mice,but not from TNFR1^(−/−)mice,failed to promote B-cell *** investigation suggested that interleukin-10 and transforming growth factor-β1 were crucial for the MDSC-mediated promotion of IgA *** results demonstrate a novel mechanism of MDSC-mediated immune regulation during tumor growth.