Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla

作     者：Yuan Gao Dong-Sheng Zhou Ping Hai Yan Li Fei Wang 

作者机构：BioBioPha Co.Ltd.Kunming 650201People’s Republic of China Department of Chemical EngineeringYibin UniversityYibin 644000People’s Republic of China 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2015年第5卷第5期

页      面：247-253页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was financially supported by “Largescale Compound Library” Project of National Development and Reform Commission of China 

主　　题：Rauvolfia tetraphylla Monoterpenoid indole alkaloid Rauvotetraphylline 

摘      要：Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety,namely rauvotetraphyllines F–H(1,3,4),17-epi-rauvotetraphylline F(2)and 21-epi-rauvotetraphylline H(5),were isolated from the aerial parts of Rauvolfia *** structures were established by extensive spectroscopic *** new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.