Microdosimetric Evaluation on the Metallic Nanoparticle-Mediated Dose Enhancement in Radiotherapeutic Proton Irradiation

作     者：Ai-Hui Feng Xiang Li Xu-Fei Wang Xiao-Wa Wang 冯爱慧;李响;王旭飞;王孝娃

作者机构：Institute of Modern Physics Fudan University Shanghai 200433 Laboratory of Nuclear Physics and Ion-beam Application Fudan University Shanghai 200433 Shanghai Proton and Heavy Ion Center Shanghai 201315 

出 版 物：《Chinese Physics Letters》 (中国物理快报（英文版）)

年 卷 期：2018年第35卷第6期

页      面：106-110页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：Supported by the National Natural Science Foundation of China under Grant Nos 1137504 and 11005019 

主　　题：Microdosimetric Evaluation on the Metallic Nanoparticle Mediated Dose Enhancement in Radiotherapeutic Proton Irradiation 

摘      要：Monte Carlo simulations are performed on the dosimetric effect of metallic nanoparticles in a clinical proton *** an in-water hitting model of a single nanoparticle,the secondar.y electrons dose,deposited around the particle surface,is calculated for the proton irradiations in a typical spread-out Bragg *** dose enhancement,as the ratio of electron doses from the target particle and background water,is evaluated for the dependence on the depth of hitting,particle size,elements,coating material and *** results indicate a significant dose enhancement on the particle surface within-200 nm,but a fast decay in further *** dose enhancement presents a consistency along the spread-out Bragg peak,a positive dependence on both the particle size and electron density,but a strong attenuation by surface *** cluster may increase the incdividual dose enhajncement by electron crossfire,but is only noticeable in a compact *** dose enhancement potentiates a radiosensitization use of metallic nanoparticles in clinical proton therapy,but challenqging meanwhile with the narrow ranqge of enhancement effect.