Calcineurin inhibitors and nephrotoxicity in children

作     者：Fei Liu Jian-Hua Mao Fei Liu;Jian-Hua Mao

作者机构：Department of NephrologyChildren's HospitalZhejiang University School of MedicineHangzhou 310003China 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2018年第14卷第2期

页      面：121-126页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：the National Natural Science Foundation of China(81470939,81270792 and 81170664) the Specialized Research Fund for the Doctoral Program of Higher Education(20120101110018) the Natural Science Foundation of Zhejiang Province(LH14H050002,LY15H050001) the Medicine&Health Technology Innovation Project of Zhejiang Province(2014KYA123) 

主　　题：Calcineurin inhibitors(CNIs) Children Nephrotic syndrome Nephrotoxicity Transplantation 

摘      要：Background Calcineurin inhibitors(CNIs)are commonly given to transplant recipients of kidneys and other solid organs and to patients with immune disorders,such as steroid-resistant nephrotic syndrome,steroid-dependent nephrotic syndrome,and frequent relapse nephrotic *** CNIs remain the most effective available immunosuppressant agent,there is clinical concern regarding possible long-term *** concern is especially significant in children who have a longer life expectancy and greater growth *** sources In this review,we analyzed the literatures to identify original articles that examined use of CNIs in children who received organ transplantation and nephropathy to assess the available evidence of their ***,Elsevier,and Tompson ISI Web of Knowledge were searched for identifying relevant *** Clinical research supports the presence of CNI-related ***,some researchers have questioned the prevalence and seriousness of chronic CNIs nephrotoxicity,especially because the pathological lesions typically associ-ated with long-term CNI use are *** researchers have focused on early markers of CNI nephrotoxicity,and the methods that may help prevent and manage *** Future research should focus on investigating early markers of CNI nephrotoxicity and strategies for improved immunosuppressant therapy,and developing alternative ***-mediated nephrotoxicity should always be taken seriously in clinic.