A MONOCLONAL ANTIBODY RADIOIMMUNOASSAY FOR AN ANTIGENIC DETERMINANT CA125 IN OVARIAN CANCER PATIENTS
作者机构：Department of Obstetrics and Gynecology Peking Union Medical College Beijing
出 版 物：《中华医学杂志(英文版)》 (Chinese Medical Journal)
年 卷 期：1986年第99卷第9期
页 面：721-726页
核心收录：
学科分类：10[医学]
摘 要：Serum CA125 (an ovarian epithelial carcinoma antigen) were determined with the monoclonal antibody assay kit. A value of 65 U/ml was taken as the upper normal limit. In all 24 healthy individuals the CA125 value was below 65 U/ml. Normal CA125 values were also demonstrated in most of the 65 patients with benign gynecologic tumors with the exception of some chocolate cysts of ovary. Among 46 patients with epithelial ovarian cancer CA125 values were above 65 U/mi in 89%. Besides, elevated CA125 was also observed in 75% of patients with metastatic tumor of the ovary and in 44% of those with germ cell carcinoma. Serital assays of CA125 were carried out on 2-9 occasions in each of the 33 patients with epithelial ovarian cancer before and after surgery or chemotherapy. The results were consistent with the clinical course of the disease in 93.0% of the ***125 levels rose whenever the disease progressed and fell to normal when complete remission was achieved. Therefore CA125 determination can be used as a reliable marker in monitoring the response to treatment. But sometimes serum CA125 remained stationary, within normal range when only a very small recurrent nodule developed.
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