Applications of post-translational modifications of FoxO family proteins in biological functions

作     者：Ying Zhao Yachen Wang Wei-Guo Zhu 

作者机构：Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Department of Biochemistry and Molecular BiologyPeking University Health Science CenterBeijing 100191China School of OncologyPeking University Health Science CenterBeijing 100191China 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2011年第3卷第5期

页      面：276-282页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the grants from the Ministry of Science and Technology of China (Grant 2011CB910100) the National Natural Science Foundation of China (Grants 30900722 and 31070691) 

主　　题：FoxO post-translational modification cancer 

摘      要：The functions of the FoxO family proteins,in particular their transcriptional activities,are modulated by post-translational modifi-cations(PTMs),including phosphorylation,acetylation,ubiquitination,methylation and *** PTMs occur in response to different cellular stresses,which in turn regulate the subcellular localization of FoxO family proteins,as well as their half-life,DNA binding,transcriptional activity and ability to interact with other cellular *** this review,we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.