The crucial roles of Th17-related cytokines/signal pathways in M. tuberculosis infection
作者机构：Unit of Anti-tuberculosis ImmunityCAS Key Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghai200031China Department of Microbiology and Immunology and Center for Primate Biomedical ResearchUniversity of Illinois College of MedicineChicago60612ILUSA
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2018年第15卷第3期
页 面：216-225页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the following research grants:The National Key Research and Development Program of China(2016YFA0502204) the National Institutes of Health R01 grants(NIH R01 HL64560/OD015092/HL129887 to ZWC)
主 题：immunotherapy miRNA STAT Th17-related cytokines
摘 要：Interleukin-17(IL-17),IL-21,IL-22 and IL-23 can be grouped as T helper 17(Th17)-related cytokines because they are either produced by Th17/Th22 cells or involved in their ***,we review Th17-related cytokines/Th17-like cells,networks/signals and their roles in immune responses or immunity against Mycobacterium tuberculosis(Mtb)*** studies suggest that Th17-related cytokine pathways may be manipulated by Mtb microorganisms for their survival benefits in primary tuberculosis(TB).In addition,there is evidence that immune responses of the signal transducer and activator of transcription 3(STAT3)signal pathway and Th17-like T-cell subsets are dysregulated or destroyed in patients with ***,Mtb infection can impact upstream cytokines in the STAT3 pathway of Th17-like *** on these findings,we discuss the need for future studies and the rationale for targeting Th17-related cytokines/signals as a potential adjunctive treatment.
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