Plasma gelsolin level predicts acute kidney injury after cardiopulmonary bypass in infants and young children
作者机构：Cardiac Intensive Care UnitThe Children's Hospital of Zhejiang University School of MedicineHangzhouChina The Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesThe Children's Hospital of Zhejiang University School of MedicineHangzhouChina Department of Thoracic and Cardiovascular SurgeryThe Children's Hospital of Zhejiang University School of MedicineHangzhouChina Department of AnesthesiologyThe First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of SurgeryUniversity of Pittsburgh School of MedicinePittsburghPAUSA
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2018年第14卷第2期
页 面：143-150页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：supported by grants from National Natural Science Foundation of China(81100050 to Shan-Shan Shi,81301612 to Xi-Wang Liu) Science and Technology Bureau of Zhejiang Province(2011C23011 to Qiang Shu) Ministry of Education Doctoral Station Foundation(20120101110049 to Qiang Shu) National Key Technology Support Program(2012BAI04B05 to Qiang Shu)
主 题：Acute kidney injury Cardiopulmonary bypass Infants Plasma gelsolin Young children
摘 要：Background Acute kidney injury(AKI)after cardiopulmonary bypass(CPB)is a common complication especially in pedi-atric *** gelsolin(pGSN)is an anti-inflammatory factor through binding with actin and pro-inflammatory cytokines in *** in pGSN has been reported in some pathologic *** purpose of the study was to determine the alterations of pGSN level in infants and young children after CPB and the role of pGSN as a predictor for the morbidity and severity of post-CPB *** Sixty-seven infants and young children at age≤3 years old undergoing CPB were prospectively *** levels were measured during peri-operative period with enzyme-linked immuno-sorbent assay and normalized with plasma total protein *** clinical characteristics of the patients were also *** In patients developing AKI,the normalized pGSN(pGSN_(N))levels significantly decreased at 6 h post-operation and remained low for 24 h post-operation as compared to the patients with *** at 6 h post-operation combining with CPB time presents an excellent predictive value for *** Decreased pGSN_(N)identifies post-CPB AKI in the patients≤3 years old,and is associated with adverse clini-cal *** findings suggest that circulating GSN in post-CPB patients may have beneficial effects on diminishing inflammatory responses.
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