A comprehensive analysis of immunoglobulin heavy chain genes in the Bactrian camel(Camelus bactrianus)

作     者：Zuoxiang LIANG Tao WANG Yi SUN Wenlong YANG Zhihong LIU Jing FEI Ying GUO Qingwei MA Qingjie PAN Liming REN 

作者机构：Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of ShandongCollege of Animal Science and TechnologyQingdao Agricultural UniversityQingdao 266109China State Key Laboratory of AgrobiotechnologyChina Agricultural UniversityBeijing 100193China Laboratory of Animal Molecular GeneticsCollege of Animal Science and Veterinary MedicineShandong Agricultural UniversityTaian 271018China Key Laboratory of Animal GeneticsBreeding and ReproductionInner Mongolia Agricultural UniversityHohhot 010018China Bioyong Technology Inc.Beijing 100080China 

出 版 物：《Frontiers of Agricultural Science and Engineering》 (农业科学与工程前沿（英文版）)

年 卷 期：2015年第2卷第3期

页      面：249-259页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Bactrian camel heavy-chain antibodies VHH γ3 

摘      要：Heavy chain only antibodies(HCAbs)represent a rare type of antibody that is devoid of light chains and the CH1 domain that have been reported in cartilaginous fish and *** analyzing transcript data and genome sequences,we conducted a comprehensive analysis of Bactrian camel immunoglobulin heavy chain *** on the transcript data,oneμgene,fiveγgenes,oneαgene and oneεgene were ***,the variable region of HCAbs(VHH)and the conventional antibodies(VH)sequences associated with theγ3,γ1a/b andμgenes were *** on these genome sequences,seven DH,six JH,μ,γ2a,γ2c,α,andεgenes and a portion of aγ3 gene were *** Kozak sequences within different VH families were found in our analysis,and the variability index differed between the VHH3 and VH3 *** analysis of the constant regions of the camelid immunoglobulin genes indicates that these genes appeared before the evolutionary divergence of Bactrian camels and dromedaries.