COMPARATIVE EFFICACY OF LEVO-PRAZIQUANTEL AND PRAZIQUANTEL IN TREATMENT OF SCHISTOSOMIASIS JAPONICA AT A SINGLE DOSE

作     者：吴鸣鹤 魏承慈 徐肇玥 袁鸿昌 连惟能 杨求吉 陈明 王才中 张肇基 刘滋德 危仁民 袁斯姣 胡林生 吴至省 

作者机构：Department of Infectious Diseases Huashan Hospital Shanghai Medical University Shanghai 200040 Department of Epidemiology School of Public Health Department of Parasitology Shanghai Medical University Jiangxi Provincial Antischistosomiasis Institute and Xingzi County Anti-Schistosomiasis Station Jiangxi Province 

出 版 物：《中华医学杂志(英文版)》 (Chinese Medical Journal)

年 卷 期：1991年第104卷第9期

页      面：732-735页

核心收录：

基　　金：This study was granted by Rockeffeller Foundation, USA/TDR WHO Ro T16/181/164 by National Natural Science Foundation, PRC 

主　　题：RABBITS 

摘      要：The result of a randomized double blind comparison of therapeutic efficacy of single doses of levo-praziquantel (L-PZQ) and praziquantel (PZQ) in the treatment of 139 matched pairs of proved cases of schistosomiasis japonica was reported, 268 were chronic early cases and 10 were late cases. The dosage of L-PZQ was 20 mg/kg, and that of PZQ was 40 mg/kg. Four and 6 months after treatment the stool-ova negative conversion rates were 94.8% and 96.3% for the L-PZQ group, and 97.1% and 94.0% for the PZQ group respectively (P0.05).