EFFECTS OF INTENTIONAL HEMODILUTION ON PULMONARY STASIS AND EDEMA IN PATIENTS AND EXPERIMENTAL ANIMALS

作     者：陈少如 郑鸿翱 张少民 许鸿举 陈晴晖 庄世才 

作者机构：Department of Pathophysiology Shantou University Medical College Shantou 515031 Department of Thoracic Surgery Second Affiliated Hospital Henan Medical University Zhengzhou 450052 

出 版 物：《中华医学杂志(英文版)》 (Chinese Medical Journal)

年 卷 期：1993年第106卷第1期

页      面：17-21页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：This study was supported by the National Natural Sciences Foundation of China presented at the International Congress on Hypoxia Pulmonary Pathophysiology held in Chongqing in 1990 

主　　题：VASCULAR-RESISTANCE BLOOD-VISCOSITY 

摘      要：The therapeutic effects of intentional hemodilution （IHD） on 64 patients of rheumatic mitral valvular disease with chronic pulmonary stasis were estimated. The mean hematocrit was decreased from 0.50±0.06 to 0.41±0.04 by withdrawing blood and replacing it with diluent. The whole blood ratio viscosity was decreased from 11.7±2.4 to 6.4±0.8 （P0.01）, the pulmonary arterial pressure was reduced from 6.4±0.6 to 4.1±0.5 kPa （0.133 kPa=1mmHg） （P0.01）, the pulmonary vascular resistance brought down from 536.0±108.0 to 315.0±62.0 dynes. s. cm（P0.01）, the cardiac output increased from 3.4±0.4 to 5.6±0.5 L/min （P0.01）, the cardiac index increased from 2.2±0.5 to 3.5±0.4 L/min/m（P0.01）, and venous oxygen saturation and oxygen content increased from 28.5±3.4%, 5.1±0.5% to 56.0±5.0%, 11.3±1.2%, respectively （P0.01）. The patients’ symptoms and signs improved significantly. The protective role of IHD in the early stage of lethal pulmonary edema induced by epinephrine in 39 rabbits and 27 rats was also observed. The experimental data show that intentional hemodilution increased the animals’ survival rate （P0.01）, reduced the pulmonary coefficient, permeability index of Evans blue and protein content in broncho-alveolar lavage fluid （BALF） （all P0.01）, and alleviated the pathomorphological changes of the lungs of animals in Group IHD were alleviated. The results suggest that HID acts well in both chronic pulmonary stasis and acute pulmonary edema.