Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling

作     者：Kai Gong Fangfang Zhou Huizhe Huang Yandao Gong Long Zhang 

作者机构：Department of Biological Sciences and BiotechnologyTsinghua UniversityBeijing 100084China Leiden University Medical CenterDepartment of Molecular Cell BiologyLeidenthe Netherland Faculty of Basic Medical SciencesChongqing Medical UniversityChongqing 400016China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2012年第3卷第10期

页      面：762-768页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Netherlands Organization for Scientific Research(NWO 918.66.066) Netherlands Initiative for Regenerative Medicine and Centre for Biomedical Genetics CSTC2012 jjjq1000 National Nature Science Foundation of China Grants 30900748 and 31171388(to H.H.) 

主　　题：LPS ERK GSK3β β-catenin cell migration 

摘      要：We investigate the role of β-catenin signaling in the response of macrophage to lipopolysaccharide(LPS)using RAW264.7 *** rapidly stimulated cytosolic β-catenin accumulation.β-catenin-mediated transcription was showed to be required for LPS induced gene expression and cell ***,ERK activation-primed GSK3β inactivation by Akt was demonstrated to mediate the LPS induced β-catenin ***,our findings suggest that suppression of GSK3β by ERK stimulatesβ-catenin signaling therefore contributes to LPS induced cell migration in macrophage activation.