Detection of Repair of the Zone of Calcified Cartilage with Osteoarthritis through Mesenchymal Stem Cells by Ultrashort Echo Time Magnetic Resonance Imaging

作     者：Quan Zhou Shao-Lin Li Ya-Jun Ma Vicki de Tal Wei Li Ying-Hua Zhao Zhou Quan;Li Shao-Lin;Ma Ya-Jun;Tal Vicki de;Li Wei;Zhao Ying-Hua

作者机构：Department of Radiology Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province) Guangzhou Guangdong 510630 China Department of Medical Imaging The Fifth Affiliated Hospital of Sun Yat-sen University Zhuhai Guangdong 519000 China Department of Radiology University of California San Diego CA 92103-8226 USA 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2018年第131卷第9期

页      面：1092-1098页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 100216[医学-运动医学] 10[医学] 

基　　金：supported in part by grants from the Science and Technology Plan Projects of Guangdong provincial, China the Tianhe District Science and Technology Project of Guangzhou city, China 

主　　题：Magnetic Resonance Imaging Mesenchymal Stem Cells Osteoarthritis Ultrashort Echo Time Zone of Calcified Cartilage 

摘      要：Objective：Currently,magnetic resonance imaging （MRI） is the most commonly used imaging modality for observing the growth and development of mesenchymal stem cells （MSCs） after in vivo transplantation to treat osteoarthritis （OA）.However,it is a challenge to accurately monitor the treatment effects of MSCs in the zone of calcified cartilage （ZCC） with *** is especially true in the physiological and biochemical views that are not accurately detected by MRI contrast *** contrast,ultrashort time echo （UTE） MRI has been shown to be sensitive to the presence of the ZCC,creating the potential for more effectively observing the repair of the ZCC in OA by MSCs.A special focus is given to the outlook of the use ofUTE MRI to detect repair of the ZCC with OA through *** limitations of the current techniques for clinical applications and future directions are also *** Sources：Using the combined keywords：＂osteoarthritis＂,＂mesenchymal stem cells＂,＂calcified cartilage＂,and ＂magnetic resonance imaging＂,the PubMed/MEDLINE literature search was conducted up to June 1,*** Selection：A total of 132 published articles were initially identified *** the 132 articles,48 articles were selected after further detailed *** study referred to all the important English literature in ***：In contrast,UTE MRI has been shown to be sensitive to the presence of the ZCC,creating the potential for more effectively observing the repair of the ZCC in OA by ***：The current studies showed that the ZCC could be described in terms of its histomorphology and biochemistry by UTE *** prospected that UTE MRI has been shown the potential for more effectively observing the repair of the ZCC in OA by MSCs in vivo.