Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

作     者：Xu-Jie Qin Tong Shu Qian Yu Huan Yan Wei Ni Lin-Kun An Pan-Pan Li Yin-E Zhi Afsar Khan Hai-Yang Liu 

作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Yunnan Key Laboratory of Medicinal ChemistryKunming 650201People’s Republic of China University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Institute of Medicinal Chemistry and Chemical BiologySchool of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006People’s Republic of China Department of ChemistryCOMSATS Institute of Information TechnologyAbbottabad 22060Pakistan 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2017年第7卷第4期

页      面：315-321页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：National Natural Science Foundation of China(Nos.31600283 and 31570363) fund of State Key Laboratory of Phytochemistry and Plant Resources in West China(No.P2017-ZZ04)from Kunming Institute of Botany,Chinese Academy of Sciences 

主　　题：Callistemon salignus Myrtaceae Meroterpenoids Cytotoxicity 

摘      要：Callisalignenes G–I(1–3),three new meroterpenoids of b-triketone and monoterpene,along with two known analogues(4 and 5),were isolated from Callistemon *** structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism(ECD)*** H(2)and I(3)have a rare sec-butyl moiety at *** 1–3 exhibited cytotoxicity against HCT116 cells with IC50 values of 8.51±1.8,9.12±0.3,and 16.33±3.3 lM,respectively.