THE INHIBITORY EFFECT OF DEFEROXAMINE ON DNA SYNTHESIS IN HUMAN LYMPHOCYTES
作者机构：InstituteofHematology People'sHospital BeijingMedicalUniversity Beijing
出 版 物：《中华医学杂志(英文版)》 (Chinese Medical Journal)
年 卷 期：1989年第102卷第12期
页 面：905-905页
核心收录：
学科分类：12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 1002[医学-临床医学] 08[工学]
摘 要：As an iron-chelating agent, deferoxamine (DFO) is widely used in treating iron poisoning and disorders of iron overload. This study demonstrates that DFO is a potent S-phase inhibitor of DNA synthesis in human lymphocytes in vitro, and this inhibitory effect of DFO is reversible by adding appropnate amounts of ferric ion. As a nontoxic and selective-S-phase inhibitor, it may play a role in immunosuppression in experimental and therapeutic situations. It may even become an auxiliary therapy for leukemia or other malignant tumors.
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