Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells

作     者：Du Wen Yanhong Xue Kuo Liang Tianyi Yuan Jingze Lu Wei Zhao Tao Xu Liangyi Chen 

作者机构：National Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Lab of Cell Secretion and MetabolismInstitute of Molecular MedicinePeking University and National Center for Nanoscience and TechnologyBeijing100871China Department of General SurgeryXuanwu HospitalCapital Medical UniversityBeijing 100053China Graduate School of the Chinese Academy of SciencesBeijing 100864China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2012年第3卷第8期

页      面：618-626页

核心收录：

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 07[理学] 

基　　金：supported by a grant from the National Natural Science Foundation of China(Grant No.30871225) a grant from Beijing Municipal Science and Technology Commission(Grant No.7121008) a grant from the Ministry of Science and Technology(Grant No.SQ2011SF11B01041) the fund from The Key Construction Program of the National“985”Project from the Department of Education of China to Peking University 

主　　题：bulk-like endocytosis clathrin-independent endocytosis dynamin diabetic KKAy mice 

摘      要：Although bulk endocytosis has been found in a number of neuronal and endocrine cells,the molecular mechanism and physiological function of bulk endocytosis remain *** pancreatic beta cells,we have observed bulk-like endocytosis evoked both by flash photolysis and trains of ***-like endocytosis is a clathrin-independent process that is facilitated by enhanced extracellular Ca^(2+) entry and suppressed by the inhibition of dynamin ***,defects in bulklike endocytosis are accompanied by hyperinsulinemia in primary beta cells dissociated from diabetic KKAy mice,which suggests that bulk-like endocytosis plays an important role in maintaining the exo-endocytosis balance and beta cell secretory capability.