Wnt pathway antagonists and angiogenesis

作     者：Bin Zhang Jian-xing Ma 

作者机构：Department of PhysiologyDepartment of MedicineThe University of Oklahoma Health Sciences CenterOklahoma CityOk 73104USA 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2010年第1卷第10期

页      面：898-906页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：sFRPs Dkk WIF-1 endostatin SERPINA3K curcumin 

摘      要：Dysregulation of the Wnt pathway has been extensively studied in multiple diseases,including some angiogenic *** signaling activation is a major stimulator in pathological angiogenesis and thus,Wnt antagonists are believed to have therapeutic potential for neovascular ***,some Wnt antagonists have been identified directly from the anti-angiogenic factor *** review summarizes the recent progress toward understanding of the roles of Wnt pathway antagonists in angiogenic regulation and their mechanism of action,and exploring their therapeutic potential.