Lycodine-Type Lycopodium Alkaloids from the Whole Plants of Huperzia serrata

作     者：Yu-Chen Liu Zhi-Jun Zhang Jia Su Li-Yan Peng Lu-Tai Pan Xing-De Wu Qin-Shi Zhao 

作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of SciencesBeijing 100039People’s Republic of China Guiyang College of Traditional Chinese MedicineGuiyangPeople’s Republic of China 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2017年第7卷第5期

页      面：405-411页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the NSFC-Joint Foundation of Yunnan Province(No.U1502223) the National Natural Science Foundation of China(No.21402212) the Science and Technology Program of Yunnan province(No 2015FB173) the CAS"Light of West China"Program and Youth Innovation Promotion Association CAS(X.D.Wu) 

主　　题：Lycopodium alkaloids Lycodine-type Huperzia serrata BACE1 inhibitory activity 

摘      要：t Three new lycodine-type Lycopodium alkaloids,namely 1-methyllycodine(1),8a-hydroxy-15,16-dehydro-desN-methyl-a-obscurine(2),N-methyl-16-hydroxyhuperzine B(3),and one new natural lycodine-type Lycopodium alkaloid,N-methylhuperzine A(4),along with 11 known analogues(5–15),were isolated from the whole plants of club moss Huperzia *** structures of 1–4 were elucidated on the basis of NMR spectroscopic and mass spectrometry *** them,compound 1 was the first lycodine-type alkaloid possessing a methyl group at *** addition,the structure of 5 was confirmed by the single-crystal X-ray crystallography data and its^(13)C NMR was reported for the first time in current *** 1–5 were tested their BACE1 inhibitory activity.