MITOCHONDRIAL FUNCTION AND TISSUE VIABILITY IN VIVO:FROM ANIMAL EXPERIMENTS TO CLINICAL *** YEARS OF FRUITFUL COLLABORATION WITH BRITTON CHANCE

作     者：AVRAHAM MAYEVSKY 

作者机构：The Mina and Everard Goodman Faculty of Life-Sciences The Leslie and Susan Gonda Multidisciplinary Brain Research Center Bar-Ilan UniversityRamat-Gan52900Israel 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2011年第4卷第4期

页      面：337-359页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

主　　题：NADHfluorescence in vivo multiparametric brain monitoring mitochondrial redox state mitochondrial dysfunction tissue energy metabolism 

摘      要：The involvement of mitochondrial dysfunction in many pathophysiological conditions and human diseases is well *** order to evaluate mitochondrial function in vitro,many experimental systems have been *** the number of in vivo monitoring systems for the evaluation of mitochondrial activities in intact animals and patients is relatively *** pioneering development of the conceptual and technological aspects ofmitochondrial monitoring,in vitro and in vivo,was done by the late *** Chance(July 24,1913
November 16,2010)since the early *** was my privilege to join his laboratory in 1972 and collaborate with him for almost four *** main achievements of our collaboration are presented in this *** activities included cycles of technology development,followed by its applications to study various pathophysiological *** the initial stage,thefirstfiber-optic
based NADHfluorometer was *** device enabled us to monitor various organs in anesthetized animals aswell as the brain of nonanesthetized small *** on,the addition of various physiological parameters to NADH monitoring enabled us to correlate mitochondrial function with other cellular *** application of the developed technology to clinical situations was a major interest of *** and indeed this goal was achieved in the last *** of today,the basic tool forNADHmonitoring and the large database of results are available for large-scale experimental and clinical applications.