The role of mitochondrial autophagy in Doxorubicininduced cardiotoxicity

作     者：聂佩 张金国 

作者机构：Jining Medical University Department of Cardiologythe Affiliated Hospital of Jining Medical University 

出 版 物：《South China Journal of Cardiology》 (岭南心血管病杂志（英文版）)

年 卷 期：2018年第19卷第1期

页      面：69-75页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：mitochondrial autophagy doxorubicin cardiotoxicity effect 

摘      要：Background Doxorubicin is a widely used drug in all kinds of chemotherapy, but its application is limited by its cardiac toxicity to some extent. Most of scholars have studied doxorubicin induced myocardial injury and cardiomyocytes death, but the specific mechanism remains unclear. Autophagy is a metabolic pathway of degrad- ing longevity protein and organelles by lysosome, especially selective autophagy which called mitochondrial au- tophagy exists in various cells. The normal range of mitochondrial autophagy helps to maintain the physiological function, otherwise, could lead to the development of disease. Recent studies have suggested that mitochondrial autophagy is involved in the progress of doxorubicin-induced cardiotoxicity. This article reviews the role of mito- chondrial autophagy in doxorubicin-induced cardiotoxicity, and how mitochondrial autophagy is involved in the occurrence and development of the progress, in order to provide a theoretical basis of prevention and treatment.