Evaluations of dielectric property and drug release profile of 5-FU patches based on plasma charged electrets

作     者：苑旺 梁合鹃 黄平 安晓强 江键 崔黎丽 

作者机构：Department of Physics and MathematicsCollege of Basic Medical SciencesSecond Military Medical University Department of Inorganic ChemistrySchool of PharmacySecond Military Medical University 

出 版 物：《Plasma Science and Technology》 (等离子体科学和技术（英文版）)

年 卷 期：2018年第20卷第5期

页      面：110-116页

核心收录：

学科分类：07[理学] 070204[理学-等离子体物理] 0702[理学-物理学] 

基　　金：National Natural Science Foundation of China(Grant No.51477175) for financial support 

主　　题：electret hypertrophic scar thermally stimulated discharge current 5-fluorouracil,patch piezoelectric coefficient 

摘      要：In the present study,the electret 5-fluorouracil patch was developed,the effective surface potential,piezoelectric coefficient d33,open-circuit thermally stimulated discharge（TSD） current spectra and shear adhesion of the patch were *** drug release profile of the patch was determined by using high performance liquid chromatography method.A stable potential difference which was positively dependent on the surface potential of the electret was generated on two sides of the *** measurements of d33 coefficient,TSD current spectra and adhesion performance showed that the electrostatic field of the electret could cause polarization and cohesive strength decreasing of the matrix molecules,change the distribution and interaction of the drug molecules in patch,therefore to increase the release of drug from the transdermal patch.