Vitamin D in prostate cancer

作     者：Donald L Trump Jeanny B Aragon-Ching 

作者机构：Inova Schar Cancer Institute Inova Health System Fairfax VA 22037 USA. 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2018年第20卷第3期

页      面：244-252页

核心收录：

学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 1002[医学-临床医学] 07[理学] 0905[农学-畜牧学] 09[农学] 071002[理学-动物学] 

主　　题：androgens CYP24A1 inflammation prostate cancer vitamin D analogs 

摘      要：Signaling through the vitamin D receptor has been shown to be biologically active and important in a number of preclinical studies in prostate and other cancers. Epidemiologic data also indicate that vitamin D signaling may be important in the cause and prognosis of prostate and other cancers. These data indicate that perturbation of vitamin D signaling may be a target for the prevention and treatment of prostate cancer. Large studies of vitamin D supplementation will be required to determine whether these observations can be translated into prevention strategies. This paper reviews the available data in the use of vitamin D compounds in the treatment of prostate cancer. Clinical data are limited which support the use of vitamin D compounds in the management of men with prostate cancer. However, clinical trials guided by existing preclinical data are limited.