Synthesis of pyrazinyl compounds from glycerol and 1,2-propanediamine over Cu-TiO_2 catalysts supported on γ-Al_2O_3

作     者：Xue Li Cheng-Hua Xu Chuan-Qi Liu Yu Chen Jian-Ying Liu 

作者机构：Air Environmental Modeling and Pollution Controlling Key Laboratory of Sichuan Higher Education InstitutesChengdu University of Information Technology Air Environmental Modeling and Pollution Controlling Key Laboratory of Sichuan Higher Education Institutes.Chengdu University of Information Technology College of Optoelectronic TechnologyChengdu University of Information Technology 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2013年第24卷第8期

页      面：751-754页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported financially by the Youth Science & Technology Foundation of Sichuan Province in China(No. 2012JQ0047) Development foundation from Air Environmental Modeling and Pollution Controlling Key Laboratory of Sichuan Higher Education Institutes(No.ZZKT2012003) 

主　　题：Catalytic cyclization Glycerol Alkyl substituted pyrazines Steric effect 

摘      要：Cu-TiO_2 catalysts supported onγ-Al_2O_3 are prepared and used in glycerol cyclization with 1,2-propanediamine to produce pyrazinyl compounds including 6-hydroxymethyl-2-methylpyrazine,5-hydroxymethyl -2-methyIpyrazine,2,6-dimethylpyrazine and 2,5-dimethylpyrazine in a fixed-bed *** is found that glycerol cylclization with 1,2-propanediamine gave a high total yield of pyrazinyl compounds（〉80%） over Cu-Ti02/γ-Al_2O_3 catalyst,and cyclization was through the reactions between activated 1,2-propanediamine and the intermediates from glycerol dehydration and *** addition,the regioselectivity of the pyrazinyl compounds was mainly controlled by the steric hindrance of the substrates during the cyclization process.