Derivation of male germ cells from induced pluripotent stem （iPS） cells： a novel and crucial source for generating male gametes

作     者：Zuping He 

作者机构：Clinical Stem Cell Research Center Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200032 China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2012年第14卷第4期

页      面：516-517页

核心收录：

学科分类：090603[农学-临床兽医学] 08[工学] 09[农学] 0906[农学-兽医学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

摘      要：One of the most significant findings in recent stem cell research is the establishment of the induced pluripotent stem （iPS） cells, because they could have critical implications in both regenerative and repro- ductive medicine. Male gametes play a crucial role in transmitting genetic information to subsequent generations, and notably there are more and more patients with azoospermia, due to genetic and environmental factors. Recent advancements on generation of male gametes from human iPS cells would bring great promise to produce patient own male gametes for treating male infertility and provide an excellent platform for unveiling molecular mechanisms of male germ cell development.