Isolation,Purification and Bioactivities of Polysaccharides from Irpex lacteus

作     者：ZHANG Na LIU Yan LUJia-hui WANG Juan YANG Shuang ZHANG Nan MENG Qing-fan TENG Li-rong 

作者机构：College of Life ScienceJilin UniversityChangchun 130012P.R.China Department of Chemistry and PharmacyZhuhai College of Jilin UniversityZhuhai 519041P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2012年第28卷第2期

页      面：249-254页

核心收录：

学科分类：090601[农学-基础兽医学] 090403[农学-农药学(可授农学、理学学位）] 09[农学] 0906[农学-兽医学] 0904[农学-植物保护] 0703[理学-化学] 

基　　金：Supported by the Pharmaceutical Development Fund of China Medical Foundation(No.20061108) 

主　　题：Irpex lacteus Polysaccharide Purification Bioactivity 

摘      要：Irpex lacteus has been widely used for treating chronic glomerulonephritis as a traditional Chinese *** water-soluble polysaccharide fractions（ILN I,ILN II,ILN III,ILA I,ILA II,ILB I and ILB II） were isolated and purified from Irpex lacteus by hot-water extraction,deproteinization,decolorization,dicthy laminoethyl（DEAE）-cellulose ion exchange and sephadex G100 chromatographies,*** average molecular weights and monosaccharide composition of these polysaccharide fractions greatly differed from each *** antitumor and antinephritis activities of the seven polysaccharide fractions were *** was found that ILN III displayed significant inhibition effects on both humar hepatocellular liver carcinoma（HepG2） and hentietta lacks（HeLa） tumor cells with IC 50 values of 60.95 and 99.95 μg/mL,*** I exhibited significant inhibition effects on murine mesangial cells（HBZT-1） with an IC 50 value of 185.06 μg/*** inhibition effects of other polysaccharide fractions on these three cells were significantly *** results suggest that the polysaccharide fractions isolated from Irpex lacteus have potential antitumor and antinephritis activities.