Radiation-induced inflammation and autoimmune diseases

作     者：Rasoul Yahyapour Peyman Amini Saeed Rezapour Mohsen Cheki Abolhasan Rezaeyan Bagher Farhood Dheyauldeen Shabeeb Ahmed Eleojo Musa Hengameh Fallah Masoud Najafi 

作者机构：School of MedicineJiroft University of Medical Sciences Department of RadiologyFaculty of ParamedicalTehran University of Medical Sciences Department of Radiologic TechnologyFaculty of ParamedicineAhvaz Jundishapur University of Medical Sciences Department of Medical PhysicsSchool of MedicineIran University of Medical Sciences Departments of Medical Physics and RadiologyFaculty of Paramedical SciencesKashan University of Medical Sciences Department of Medical Physics and Biomedical EngineeringFaculty of MedicineTehran University of Medical Sciences (International Campus) Department of PhysiologyCollege of MedicineUniversity of Misan Research center for molecular and cellular imagingTehran University of Medical Sciences Department of ChemistryFaculty of ScienceIslamic Azad University Radiology and Nuclear Medicine Department School of Paramedical Sciences Kermanshah University of Medical Science 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2018年第5卷第1期

页      面：62-71页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

主　　题：Radiation Inflammation Autoimmune diseases Thyroid Diabetes 

摘      要：Currently,ionizing radiation(IR)plays a key role in the agricultural and medical industry,while accidental exposure resulting from leakage of radioactive sources or radiological terrorism is a serious *** to IR has various detrimental effects on normal *** an increased risk of carcinogenesis is the best-known long-term consequence of IR,evidence has shown that other diseases,particularly diseases related to inflammation,are common disorders among irradiated *** disorders are among the various types of immune diseases that have been investigated among exposed *** diseases and diabetes are two autoimmune diseases potentially induced by ***,the precise mechanisms of IR-induced thyroid diseases and diabetes remain to be elucidated,and several studies have shown that chronic increased levels of inflammatory cytokines after exposure play a pivotal ***,cytokines,including interleukin-1(IL-1),tumor necrosis factor(TNF-α)and interferon gamma(IFN-α),play a key role in chronic oxidative damage following exposure to ***,these cytokines change the secretion of insulin and thyroid-stimulating hormone(TSH).It is likely that the management of inflammation and oxidative damage is one of the best strategies for the amelioration of these diseases after a radiological or nuclear *** the present study,we reviewed the evidence of radiation-induced diabetes and thyroid diseases,as well as the potential roles of inflammatory *** addition,we proposed that the mitigation of inflammatory and oxidative damage markers after exposure to IR may reduce the incidence of these diseases among individuals exposed to radiation.