Gold（Ⅰ）-Catalyzed Diastereo- and Enantioselective Synthesis of Polysubstituted Pyrrolo[3,4-d][1,2 ]oxazines

作     者：MeiZhang Xiaoyu Di Mingrui Zhang Junliang Zhang 

作者机构：Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of Chemistry East China Normal University 3663 N Zhongshan Road Shanghai 200062 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2018年第36卷第6期

页      面：519-525页

核心收录：

学科分类：081704[工学-应用化学] 081705[工学-工业催化] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学] 

基　　金：We are grateful to the National Natural Science Foundation of China (21425205)  Ministry of Education of China  Ying Tung Education Foundation (121014) for financial support 

主　　题：gold(Ⅰ)-catalysis heterobicyclic pyrroles oxime ethers nitrones tandem reaction 

摘      要：A gold（I）-catalyzed highly diastereo- and enantioselective intermolecular cycloaddition of oxime ethers with nitrones under mild conditions was developed, which provides an facile access to optically pure highly substituted pyrrolo[3,4-d][1,2]oxazines. The salient features of this reaction in- clude general substrate scope, high efficiency, high enantioselectivity, readily available starting materials, and the use of commercially available ligand.