Peripheral Leptin Signaling Mediates Formalin-Induced Nociception
Peripheral Leptin Signaling Mediates Formalin-Induced Nociception作者机构：Department of Integrative Medicine and Neurobiology School of Basic Medical Sciences Institutes of Brain Science Brain Science Collaborative Innovation Center State Key Laboratory of Medical Neurobiology Institute of Acupuncture and Moxibustion Fudan Institutes of Integrative Medicine Fudan University Shanghai 200032 China WuXi AppTec Shanghai 200131 China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2018年第34卷第2期
页 面：321-329页
核心收录：
学科分类：0710[理学-生物学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 100602[医学-中西医结合临床]
基 金：supported by the National Natural Science Fundation of China(81473749,81371247,31600852,and 31421091) WuXi AppTec
主 题：Leptin Obesity Formalin test Nociception
摘 要：Accumulating evidence suggests that obesity is associated with chronic pain. However, whether obesity is associated with acute inflammatory pain is unknown. Using a well-established obese mouse model induced by a highfat diet, we found that:(1) the acute thermal pain sensory threshold did not change in obese mice;(2) the model obese mice had fewer nociceptive responses in formalininduced inflammatory pain tests; restoring the obese mice to a chow diet for three weeks partly recovered their pain sensation;(3) leptin injection induced significant phosphorylation of STAT3 in control mice but not in obese mice,indicating the dysmodulation of topical leptin–leptin receptor signaling in these mice; and(4) leptin–leptin receptor signaling-deficient mice(ob/ob and db/db) or leptin–leptin receptor pathway blockade with a leptin receptor antagonist and the JAK2 inhibitor AG 490 in wildtype mice reduced their nociceptive responses in formalin tests. These results indicate that leptin plays a role in nociception induced by acute inflammation and that interference in the leptin–leptin receptor pathway could be a peripheral target against acute inflammatory pain.
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