The relationship between serum zinc levels and rheumatoid arthritis activity

作     者：Elham Rajaee Karim Mowla Ali Ghorbani Mehrdad Dargahi-Malamir Marzieh Zarei Faraj Allah Rahimikhah 

作者机构：Golestan Hospital Clinical Research Development Unit Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Nephrology Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Shiraz University of medical Sciences Shiraz Iran Department of Internal Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz 1ran 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2018年第13卷第1期

页      面：51-55页

核心收录：

学科分类：08[工学] 0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0832[工学-食品科学与工程（可授工学、农学学位）] 0821[工学-纺织科学与工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1001[医学-基础医学(可授医学、理学学位)] 0836[工学-生物工程] 082101[工学-纺织工程] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 0713[理学-生态学] 083203[工学-农产品加工及贮藏工程] 

基　　金：by Dr. Faraj Allah Rahimikhah submitted to the Faculty of Medicine of Ahvaz Jundishapur University of Medical Sciences in partial fulfillment of the requirement for the degree of the specialty in Internal Medicine supported by the Vice-Chancellor of University in Researches, Ahvaz Jundishapur University of Medical Sciences 

主　　题：serum zinc level rheumatoid arthritis disease activity score DAS28 

摘      要：OBJECTIVES： Rheumatoid arthritis （RA） is one of the most prevalent chronic autoimmune diseases; it typically involves the hands, wrists, ankles, and eventually all joints. Some studies have reported that zinc serum levels are lower in patients with RA than in healthy individuals. MATERIALS and METHODS： Seventy-nine patients with RAwere selected. The patients were all less than 75 years old and were diagnosed by a rheumatologist. Serum zinc levels were measured using the flame photometry method with a blood sample of 5 mL. The relationship between the average serum zinc level and disease activity was analyzed based on the DAS28 scoring scale for different RA groups. The significance threshold was set atp 〈 0.05. Data analyses were implemented in SPSS 22.0. RESULTS： There was a significant inverse relationship between the serum zinc levels and disease activity. Chi-square tests were used to compare zinc serum levels with respect to disease activity. There were significant differences in zinc levels among three groups of patients with different levels of disease severity, such that disease activity increased as the serum zinc level decreased （p 〈 0.001）. CONCLUSION： There was a significant inverse relationship between the serum zinc level and RA activity based on the DAS28 score. Therefore, it is recommended that mineral deficiencies should be addressed by optimizing the zinc supply along with other standard medications in order to reduce RA activity.